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    Impact of human immunodeficiency virus infection on survival and acute toxicities from chemoradiation therapy for cervical cancer patients in a limited-resource setting

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    Grover_IJROBP_2018.pdf (454.0Kb)
    Date
    2018-05-01
    Author
    Grover, Surbhi
    Yeager, Alyssa
    Chiyapo, Sebathu
    Bhatia, Rohini
    MacDuffie, Emily
    Puri, Priya
    Balang, Dawn
    Ratcliffe, Sarah
    Narasimhamurthy, Mohan
    Gwangwava, Elliphine
    Tsietso, Sylvia
    Kayembe, Mukendi K.A.
    Ramogola-Masire, Doreen
    Dryden-Peterson, Scott
    Lin, Lilie L.
    Zetola, Nicola M.
    Viswanathan, Akila N.
    Mahantshetty, Umesh
    Publisher
    Elsevier, https://www.elsevier.com/en-xm
    Link
    https://pubmed.ncbi.nlm.nih.gov/29619965/
    Type
    Published Article
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    Abstract
    Purpose—To prospectively compare survival between human immunodeficiency virus (HIV)-infected versus HIV-uninfected cervical cancer patients who initiated curative chemoradiation therapy (CRT) in a limited-resource setting. Methods and Materials—Women with locally advanced cervical cancer with or without HIV infection initiating radical CRT in Botswana were enrolled in a prospective, observational, cohort study from July 2013 through January 2015. Results—Of 182 women treated for cervical cancer during the study period, 143 women initiating curative CRT were included in the study. Eighty-five percent of the participants (122 of 143) had stage II/III cervical cancer, and 67% (96 of 143) were HIV-infected. All HIV-infected patients were receiving antiretroviral therapy (ART) at the time of curative cervical cancer treatment initiation. We found no difference in toxicities between HIV-infected and HIV-uninfected women. The 2-year overall survival (OS) rates were 65% for HIV-infected women (95% confidence interval [CI] 54%-74%) and 66% for HIV-uninfected women (95% CI 49%-79%) (P = .70). Factors associated with better 2-year OS on multivariate analyses included baseline hemoglobin >10 g/dL (hazard ratio [HR] 0.37, 95% CI 0.19-0.72, P = .003), total radiation dose ≥75 Gy (HR 0.52, 95% CI 0.27-0.97, P = .04), and age <40 years versus 40-59 years (HR 2.17, 95% CI 1.05-4.47, P = .03). Conclusions—Human immunodeficiency virus status had no effect on 2-year OS or on acute toxicities in women with well-managed HIV infection who initiated curative CRT in Botswana. In our cohort, we found that baseline hemoglobin levels, total radiation dose, and age were associated with survival, regardless of HIV status.
    URI
    http://hdl.handle.net/10311/2251
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